Macrolides

Tx of  respiratory tract infections, H. pylori, skin, PID, skin, bacterial STD's, MRSA
Take on empty stomach

  • Prototype drug: Azithromycin (Zithromax) - "Z-pack"
    • monitor for hepatotoxicity and ototoxicity
    • assess liver enzymes on a regular basis
  • Other Drugs: Erythromycin, Clarithromycin, Clindamycin, Vancomycin
    • monitor for renal and hepatic function
    • monitor for signs of colitis (diarrhea, abdominal cramping)
    • monitor for ototoxicity
  • Vancomycin: monitor for red man syndrome, nephrotoxicity (creatinine and Urine output); peak and through levels; infuse slowly - may cause IV site pain.
  • Erythromycin: drug of choice when penicillin is not an option due to hypersensitivity

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